Cytotoxicity of leaves, stems, and flowers of Kecubung (Datura metel) extracts using the Brine Shrimp Lethality Test (BSLT) method

Brine shrimp (Artemia salina) cytotoxicity assays (BSLT) are one of the commonly used cytotoxic test methods to assess a plant extract's pharmacological activity and toxicity. Thus, this study aimed examine toxic levels Kecubung (Datura metel) leaves extracted using different solvents, namely ethanol ethyl acetate. The results showed that LC50 value flower ethanol, acetate, leaf stem acetate extracts had an 1000, which was included in category. is 121.044 ppm, 105.89 639.589 635.276 ppm. Ethanol extract at concentration 1000 ppm highest mortality with percentage 60% total number A. salina. 250 67% 70% Meanwhile, obtained 100% salina first 6 hours. result shows very compared other concentrations.Keywords:ToxicityArtemia salinaLC50Ethyl acetateEthanol